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MK4 vs MK7

(deactivated member)
on 1/4/10 7:23 pm - PA
Laugh Out Loud
on 1/4/10 7:57 pm
I bookmarked this post from a couple of weeks ago:

http://www.obesityhelp.com/forums/DS/4088102/Vit-k/

About half way down the article is good info about absorption time and availability of MK4 vs MK7; also consider if you are on blood thinners.  Hope this helps.

Cindy
(deactivated member)
on 1/5/10 6:55 am - PA
J G.
on 1/5/10 11:34 am
DS on 06/23/08 with
Annette, you said:   I am still wondering then, why some supp co's would offer MK4 - its not like its any cheaper than the MK7?

I think the article you posted answers your question and one that I had.  I had been wondering why so much of the research used the MK-4.  (I should have known to follow the money trail.)  Well, it says that the Mk-4 is a synthetic compound so I assume there is a high profit margin for both the manufacturer and the supp co's.  And... the company that makes the MK-4 sponsored the studies, so that's why they are using the MK-4.  They looking for more positives on the product they sell.  Geesh!  The article states:

 The limited data available, however, point towards MK-7 as most potent K-vitamin.
J G.
on 1/5/10 2:29 am
DS on 06/23/08 with
Its been a while since I looked into this,but I recall thinkin that it was like the  difference between buying greek yogurt and regular.  Much more protein in the greek. 

MK-4 remains active in human blood for only a few hours after ingestion. The MK-7 form of vitamin K2, on the other hand, remains bioavailable in the human body many days after ingestion.  So i don't think the higher mcgs in the MK-4 really get you anything.

(deactivated member)
on 1/5/10 6:57 am - PA
nickn
on 2/25/10 9:26 am
If the body is starved for MK4 then it would make sense that its half life would be shorter. Therefore the half life of a vitamin in the body does not necessarily have anything to do with bioavailability. 

These two links have much more information on the real differences between MK4 and MK7:

http://wholehealthsource.blogspot.com/2009/03/are-mk-4-and-mk-7-forms-of-vitamin-k2.html

http://wholehealthsource.blogspot.com/2008/06/vitamin-k2-menatetrenone-mk-4.html 

In particular:

"The investigators found that MK-4 strongly activates transcription of two specific genes in osteoblast cells. Osteoblasts are cells that create bone tissue. The genes are GDF15 and STC2 and they're involved in bone and cartilage formation. They tested K1 and MK-7, and in contrast to MK-4, they did not activate transcription of the genes in the slightest. This shows that MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have."

Also, MK4 is most likely the activator that Dr. Weston Price found was needed in combination with Phosphorus, Vitamin A, D and calcium to regrow decayed teeth.