It is recommended that you start at 1000mcg a day at the beginning and adjust from there from your labs. I would take the 2500mcg every other day. They are right you do pee out the excess but if it gets high enough, they dont' know the ramifications are. There was someone on the boards yestarday with a level of 5000, I have never heard of a level that high. Ideally we want our level to be between 1200 and 1500 but it can be up to 2000. We really dont' want it over 2000. I was greater than 2000 for about 2 years but the lab didnt' give an exact number, so I dont' know how much greater. My hematologist (doctor that specializes in blood disorders and anemias) told me not to worry about it, I was just peeing out the excess. After awhile, I decided to cut my dose but by doing that my levels went all the way down to 1200 and I am exhausted all the time, so I increased my dose back to where it used to be. I would rather have a level of 2000 then 1200.