I've had to take both, daily, for over 5 years now. One scoop of the generic miralax mixed in my water bottle with a little bit of crystal lite. I take one colace pill in am and one in pm. In the beginning, I needed like 2 colace am and pm. I don't think timing is an issue with the miralax, since it's not a stimulant - BUT if I don't do it daily, I'm in trouble pretty quick. I had a bowel obstruction recently, following surgery - just because I stopped this routine while in the hospital.