As a person with osteo arthritis literally from head to toe, I can say from experience and the advice given by my rheumatologist, neuro-surgeon, and numerous orthopedics and sports medicine specialists , drugs like acetominophen have had almost no effect on arthritis pain and stiffness. It was explained to me long ago that taking drugs which were not anit-inflammatory could possibly mask pain, as in narcotic drugs, but would do nothing for the stiffness and the resulting pain of severe arthritis. I am not talking about occasional pain. I am referring to pain resulting from cervical and lumbar spinal stenosis, bone on bone both knees, and spondylolesthesis. Taking Tylenol on a reg basis in large doses would just destroy my liver without any significant pain relief. Anyone with severe arthritis knows this and has tried just about everything. Each person knows what works for them, and what allows them to function at a minimal level. When I have to go to acetomenohen for a week or two prior to surgery my life becomes almost unbearable, but I do it because there is no choice. Period.. Even an occasional narcotic pain killer does not improve the situation the way even ibuprofen does. It is a big issue is deciding which surgery to have for weight loss. Orthopedic says he cannot see a time when I will not need some type of n-said, even with both knees replaced, and back surgery for the stenosis. Weight loss will definitely help and may lessen the need for any pills, but i have to get to that point first.