Hi, I'm sorry your mom is having troubles. I take the same dose as your mom is taking and have had to go off of it for 4 months a few years ago. My bld. sugars were much worse after being on it. It is a drug in it's own category and it just does wonders for diabetics but the GI side effects are something that often do subside once you get used to them. I have been on insulin, many of the drugs people have posted, actose caused wt. gain of 40# in 6 weeks YUK. Been on Byetta, 3 different insulins, all kinds of stuff and metformin is the best because it makes the body more sensitive to it's own insulin. Hope she will feel better. Agree that fiber, increasing fluids, checking with doc, and possible XR may help. Good luck.