Is Aspercreme an NSAID???
H.a.l.a RNY 5/14/2008 SAND...
"Failure is not falling down, It is not getting up once you fell..."
"So pick yourself up, dust yourself off, and start all over again...."
on 7/29/09 6:05 pm
"Prostaglandins are natural chemicals that serve as messengers to promote inflammation. By inhibiting the body's production of prostaglandins, NSAIDs decrease inflammation. However, certain prostaglandins also are important in protecting the stomach lining from the corrosive effects of stomach acid as well as playing a role in maintaining the natural, healthy condition of the stomach lining.
These protective prostaglandins are produced by an enzyme called Cox-1. By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect prostaglandins in the stomach than others, and, therefore, have a lower risk of causing ulcers.
While contact with the stomach (by taking NSAIDs orally) can make things worse, NSAIDs can have this effect no matter how they are administered; by IV, by patch, by nasal spray, etc."
on 7/29/09 9:06 pm
How do NSAIDs work and how do they cause stomach problems?
Prostaglandins are natural chemicals that serve as messengers to promote inflammation. By inhibiting the body's production of prostaglandins, NSAIDs decrease inflammation. However, certain prostaglandins also are important in protecting the stomach lining from the corrosive effects of stomach acid as well as playing a role in maintaining the natural, healthy condition of the stomach lining. These protective prostaglandins are produced by an enzyme called Cox-1.
By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect prostaglandins in the stomach than others, and, therefore, have a lower risk of causing ulcers. The means of administration of NSAIDs is irrelevant, as the resulting inhibition of prostaglandins occurs systemically once the medication is absorbed. So taking a shot, wearing a patch, applying a topical preparation, or inhaling a nasal spray will also have the same effect.
"Oh sweet and sour Jesus, that is GOOD!" - Stephen Colbert Lap RNY 7/07-- Lap Gallbladder 5/08--
Emergency Bowel Repair 6/08 -Dr. Meilahn, Temple U. Upper and Lower Bleph/Lower Face Lift
Fraxel Repair 2/09-- Lower Bleph Re-Do 5/09 -Dr. Pontell, Media PA Mastopexy/Massive
Brachioplasty/ Extended Abdominoplasty (plus Mons Lift and Upper Leg lift) / Hernia Repair
6/24/09 ---Butt Lift and Lateral Thighplasty Scheduled 7/6/10 - Dr. Ivor Kaplan VA Beach
Total Cost: $33,500 Start wt: 368 RNY wt: 300 Goal wt: 150 Current wt: 148.2 BMI: 24.7
wondering if the shoulder pain is gas -related, mine was in my left shoulder. keep on walking!
RNY 6/16/09 - Last weighed 10/27/2011 weighed 151 lost 52 pounds 66% toward personal goal of 125, six pounds from unofficial unpretentious goal of 145lbs......basically very happy. boo-rah, RNY!
Here's an article from www.sportsinjurybulletin.com; it doesn't address post-RNY users, of course. It's likely that the blood levels of salicylate are much lower than those seen after taking aspirin or sodium salicylate orally. Does this make it safe for RNYers? I have no idea.
Trolamine salicylate: The ‘Deep-Heat’ debateTrolamine salicylate is the key ingredient to most creams that claim when applied directly to the skin can cure muscular aches and pains. Until recently however, the validity of trolamine salicylate as a sound tool for curing muscle-pain has been highly contested.
The First Test
Just over ten years ago, researchers at a Veterinarians Medical Center in Philadelphia applied trolamine salicylate skin cream on to the knees of both dogs and humans. The canines with trolamine rubbed into their knees had 20 times as much salicylate in the underlying muscles; compared to those who were taking aspirin orally (salicylate is the active ingredient in aspirin).
The research documented one very important fact: even though pill-popping pooches had higher BLOOD levels of salicylate, animals using skin cream had much more of the drug in their tendons, ligaments, cartilage, and joint cavities, where it really mattered, and where the chemical could actually relieve pain and inflammation.
In the Philadelphia research, results with humans were similar, with ample amount of salicylate building up in joint cavities. Actual pain relief was just as good with the salicylate skin cream, compared to ingesting aspirin orally. Plus, the researchers noted one special cream advantage: the ointment rapidly penetrated the skin and then lingered in the underlying muscles and connective tissues for long periods of time, only slowly drifting into the blood stream to be carried away. Overall, the skin cream removed discomfort with none of the side effects or the oral medicine.
The Second Findings
In a more recent test of trolamine salicylate, packaged in a commercial product called Aspercreme, scientists at the Mount Sinai Medical Center in Miami asked 22 males and 12 females to perform three sets of 20 repetitions of biceps curls each day for five consecutive days in order to induce significant muscle soreness. Four times each day, the study subjects rubbed one-half ounce of cream onto the skin directly over the biceps muscles. Half of the subjects rubbed in Aspercreme, the other half employed a placebo cream. Unaware of which cream they were actually using, subjects rated biceps soreness on a O to 10 scale several times a day.
As it turned out, the Aspercreme provided three main benefits:
1. Muscle soreness appeared within 12 hours after initial exercise for the placebo users but took 24 hours to appear for Aspercreme appliers.
2. The amount of pain experienced was significantly lower for Aspercreme users.
3. Pain persisted for one day less with Aspercreme.
Concluding the trolamine debate
Analgesic creams containing 10 per cent trolamine salicylate really do work. There's also the intriguing possibility that a bit of skin cream rubbed on one of your body's 'hot spots' BEFORE a workout may actually reduce the amount of inflammation and pain which may be experienced after the session is over.