When I did the towel thing, I started it IMMEDIATELY after the seroma was aspirated. I also tried to only shower every other day so that I could leave it rolled up across the spot for as long as possible. This is what finally kept mine from coming back. I'd try it. It certainly can't hurt.
I'd also talk to your surgeon about what he wants you to do if it comes back while you're gone. Mine wasn't that big and I never got a fever or anything, so I think I'd have been fine to wait to return to get it aspirated again (if needed). I think they got abot 60cc that last time they aspirated it. He might think you can wait or might tell you to watch for certain things and head to an ER if they occur.
ETA: When I stuffed the towel in there it was TIGHT. It was actually almost uncomfortable, it was so tight. If it shifted and pressed on another area it would hurt and I'd have to move it. It also made me, temporarily, lopsided due to so much compression on one side. (Went away a couple of hours after removing it.) So, make sure it's REALLY tight. The point it so keep the skin pressed against the other tissues so tightly that there is no way for fluid to get in there.