Plavix...Aspirin...and the pouch

cabin111
on 7/31/08 6:38 am
So I am now on 1 Plavix and 1 Aspirin per day.  Both can irratate the pouch and small intestines.  So my questions to all of you is should I take one in the morning and one in the evening for easier digestion.  Any tricks to coat the pouch?  Would adding coffee be a no no with two items that are already hard to digest?  Those with solid ideas and thoughts please respond.  Brian  PS I know if I take coated aspirin it will help.
snicklefritz
on 7/31/08 7:33 am - Cincinnati, OH
I think coffee is going to irritate it more. I'll ask some gurus to see what other people do also. I think maybe a milk based protein shake might help also.
Steve Bacher
on 8/1/08 12:18 am - Louisville, KY
Not sure about the Plavix but I have been taking an aspirin a day for several years.  After my bypass two years ago my surgeon said I could continue taking it each day.  He said to just be sure it was coated and make sure I take it with food.  Have not had any problems with it.

As far as coffee goes all I can say is just take it easy and see how it goes for you.  I drink a couple of cups each morning and usually have no problem.  It will occasionally bother me a bit but the same was true before surgery if I drank too much of it.

Steve
foobear
on 8/2/08 7:08 am - Medford, MA
For a lot of us, coffee doesn't seem to be a problem.  However, if you're already taking a ****tail of drugs for antiplatelet therapy AND have had RNY gastric bypass, adding or continuing coffee might be just enough to push you over the edge.  Check with your doctor, but I'd hold off on the coffee for now.

In the same "vein", I'd ask your doctor whether it would be OK to take one in the AM and the other in the PM, and not try doing that  on my own.

Here's an abstract of an article which addresses the use of Plavix (clopidogrel) in gastric bypass patients.  Sounds scary, except that there's a reason that antiplatelet drugs are prescribed after a stent is inserted; it's a matter of the risk/benefit ratio assessed by your cardiologist.

Surg Obes Relat Dis. 2007 Jul-Aug;3(4):443-5. Epub 2007 Apr 2. Links

Risk of massive upper gastrointestinal bleeding in gastric bypass patients taking clopidogrel.

Caruana JA, McCabe MN, Smith AD, Panemanglore VP, Sette Camara D.

Department of Surgery, Sisters of Charity Hospital, Buffalo, New York, USA.

BACKGROUND: The antiplatelet drug clopidogrel (Plavix) is widely used in patients who have undergone coronary artery stenting or had a stroke. Because morbid obesity is associated with atherosclerosis, some of these patients are candidates for weight loss surgery. We chose to determine the risk of upper gastrointestinal bleeding after gastric bypass in patients taking clopidogrel. METHODS: Patients who took clopidogrel after gastric bypass were identified by specific review of the subset of patients who had had upper gastrointestinal bleeding requiring hospital admission and transfusion. All who bled underwent emergency endoscopy. RESULTS: Of 11 patients taking clopidogrel, 4 (36%) presented with significant upper gastrointestinal bleeding 25-234 days after gastric bypass. All stopped bleeding with discontinuation of the drug and treatment with an intravenous proton pump inhibitor. CONCLUSION: Gastric bypass patients appear to be at high risk of bleeding complications when taking clopidogrel. On the basis of the available published data from another high-risk group (i.e., those with a history of peptic ulcer disease), co-treatment with omeprazole may be indicated when clopidogrel must be continued.

PMID: 17400519 [PubMed - indexed for MEDLINE]

It's not at all uncommon to prescribe a PPI like Prilosec (omeprazole) to decrease the risk of upper GI bleeding when taking Plavix (clopidogrel), especially in combination with aspirin.  And that's for people with normal GI tracts!  This can be even more serious for post-op RNYers.  The problem is that just about every PPI (such as omeprazole) tends to reduce the antiplatelet effects of clopidogrel; this drug interaction is only recently come to prescribers' attention, and it's not yet clear whether it has any clinical implications.

/Steve


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