Study - Gastric Bypass Increases Risk for New-Onset Alcohol Abuse

PatXYZ
on 10/11/11 2:12 pm
I have several concerns about this. This is a conference presentation and not a study that has been peer-reviewed and published. Presenting this at a conference is a much lower threshold for its veracity than publishing.

Self report on behaviours more than 5 years old (drinking habits prior to surgery) are also going to be problematic due to the time scale involved and how people tend to colour thier past based on their present (ie - concerns about present drinking might evoke an underestimation of prior drinking habits). Also, how were the patients selected? Voluntary phone interviews are going to suffer from selection bias.

I'm also confused by some of the numbers and thier interpretation. It says 6.5% had problem drinking in the 6 month period before surgery and this strongly indicated problem drinking post-op, which totalled 9% of the post-ops surveyed. But then it says that 7% of the post-op problem drinkers never had pre-op drinking problems, which only leaves 2% from an original 6.5%, so does that mean that 70% (4% out of 6.5%) of the people who were problem drinkers in the 6 months before surgery suddenly weren't problem drinkers after surgery? Hell, that makes bariatric surgery one of the best cures around for problem drinking!

Looking at Canadian government statistics, 8.9% of people reported alcohol abuse behavior in 2010 that would fit the same criteria in this survey. Would this number even be meaningfully different (statistically significant) compared to 9% of WLS post-ops? Doubtfully.

Lastly, there is also no control group of non-WLS people of around the same compilation of age/gender/race to consider whether there may have been other factors that contributed to the development of problem drinking within a similar time period. At best this study points to a correlation! Correlation does not equal causation!

I'm not saying that a connection isn't possible, this just isn't the study that proves it. Even if you take what the study is saying at face value, the sky isn't falling. There is a disproportionate concern about addiction to alcohol and pain meds post-op on these boards and the numbers simply don't support the amount of worry (paranoia?) out there.
Amy W.
on 10/12/11 2:40 am - Bellingham, WA
Thank you PatXYZ for injecting some intelligent reasoning into this thread. While medical conferences and physician presentations can indeed be helpful and shed some light on disease processes, I would agree that this one falls short of conclusive evidence of any kind.

Yes alcohol does affect us to a greater degree post surgery, however that fact in and of itself is not likely to cause you to suddenly exhibit addictive behaviors in your 40's.

I think that the biggest factor they have overlooked is cross addiction: which means substituting one addiction for another and has absolutely nothing to do with physical anatomy btw.
        
waist @ 29.5 in, chest @ 33 in, hips @ 35 in, thighs @ 21 in...inspiration can lead to greatness whether it comes from within or from others, rock it out girls and guys!   
Yehuda G.
on 10/11/11 12:01 pm
I understand that the anatomy of the surgery can increase the risk of cross addiction. However, there is also the stresses of extreme rapid wl that can lead to cross addiction. Most people would think you lose 200-300 pounds and you must be happy. The truth is after being so severely obese for so long it is very hard to relearn how to live in a thin body. I know most can't understand that, but those who are extremely severe obese tend to have more of these problems and cross addiction. Learn to live thin before touching any booze is my advice.
Citizen Kim
on 10/11/11 12:49 pm - Castle Rock, CO
Interesting that they define 12 units per week as abuse/problem drinking whereas the UK define 14 as the maximum recommended per week - I think the US recommend 7 per week maximum ...

I do think the US culturally defines alcohol addiction/abuse differently to Europe.   Thankfully I am European and have always had a relatively healthy relationship with alcohol (certainly by my cultural definition)!

Proud Feminist, Atheist, LGBT friend, and Democratic Socialist

glzgowlass
on 10/12/11 11:09 am - VA
RNY on 09/14/11 with
Gawd, don't mention the UK!  I can't believe how bad the drinking culture has gotten (mostly among the young) compared to when I was their age.   -And I had my moments. 

HW: 218, SW: 204, CW: 139 GW: 112-119
             

MyLady Heidi
on 10/12/11 12:07 am
If I wanna get sick I will eat a chocolate bar, alchohol holds no appeal to me whatsoever, hasn't since I was a teenager, I have no desire to relive pewking on my shoes ever again.  I am too lazy to be addicted to anything, it means I have to actively seek something out, that just isn't going to happen.
(deactivated member)
on 10/12/11 2:43 am - Santa Cruz, CA
How about another "Duh" study for the empty skin???

Or maybe about how if you eat something too fast it might get stuck and hurt???
So Blessed!
on 10/12/11 3:12 am

From Medscape Medical News

Gastric Bypass Patients at Risk for Alcohol Abuse

Caroline Helwick

 

May 10, 2010 (Chicago, Illinois) — Patients who undergo gastric bypass surgery are at greater risk for alcohol abuse than similar obese patients undergoing restrictive procedures. Bariatric surgery patients, regardless of the type of procedure, are also more likely to be hospitalized for a psychiatric illness than the general population, Swedish investigators reported here at Digestive Disease Week 2011.

Patients who underwent gastric bypass surgery had a 2-fold increased risk for inpatient treatment for alcohol abuse, compared with patients who had a restrictive procedure such as gastric banding, reported Magdalena Plecka Östlund, MD, from the Karolinska Institutet in Stockholm, Sweden.

"Patients undergoing gastric bypass should be carefully counseled on alcohol consumption," she suggested. "In addition, caregivers should be aware of the greater potential for alcohol abuse after surgery so that treatment can be sought if problems arise."

Population-based studies have found that obese people are more likely than the general population to suffer from mood and anxiety disorders, and there are reports that gastric bypass patients are overrepresented in substance abuse treatment programs, she noted. The Swedish study explored these possible associations.

The retrospective cohort study compared 12,277 patients who underwent antiobesity surgery in Sweden between 1980 and 2006 with a matched control cohort of 122,770 people sampled from the general population. The primary surgical procedures were gastric bypass, vertical banded gastroplasty, and gastric banding, which were conducted in almost equal proportions.

The mean patient age at surgery was 40 years; the mean follow-up time was about 9 years.

Compared with the general population, the bariatric population was significantly more likely to be treated for depression (hazard ratio [HR], 1.9), attempted suicide (HR, 2.7), substance abuse (HR, 2.7), and alcoholism (HR 1.7) before surgery, Dr. Östlund reported.

They were not, however, more likely to be hospitalized for psychosis. The lack of association with psychosis was seen with both gastric bypass surgery and restrictive procedures. Other than this disorder, both types of intervention were associated with hospitalization for a psychiatric disorder.

The gastric bypass surgery cohort had higher HRs than the restrictive surgery cohort for substance abuse (HR, 3.8), suicide attempt (HR, 4.1), alcohol abuse (HR, 4.0), and depression (HR, 2.4). For the restrictive surgery cohort, these HRs were, respectively, 1.4, 2.4, 1.2, and 1.8, she said.

Alcoholism Greater After Gastric Bypass

Especially notable was the higher rate of inpatient treatment for alcoholism after gastric bypass surgery, she said. Prior to bariatric surgery, there was no difference in inpatient treatment for alcoholism between patients undergoing gastric bypass and those undergoing a restrictive procedure; however, after surgery, the gastric bypass patients had a 2.3-fold risk of being hospitalized for alcoholism, compared with the restrictive cohort. They also had a 2.5-fold risk of being treated for a substance abuse disorder.

She said the association is most likely due to the altered metabolism of alcohol that occurs after gastric bypass. "A large portion of the stomach is bypassed and the alcohol passes straight to the small intestine and into the blood, where we see increased alcohol concentrations," she said.

Commenting at a press conference, John Morton, MD, director of bariatric surgery at Stanford University Medical Center in Palo Alto, California, elaborated: "We have done studies on alcohol metabolism and it is remarkable to see what a single glass of wine will do. People become legally intoxicated quickly, and there are physiologic reasons for this. You lose first-pass metabolism and the alcohol goes directly into the intestine, which is lined with villi that absorb alcohol extremely well," he explained. "It is important to counsel patients ahead of time. Just warn them that not only should they not eat as much after surgery, they probably should not drink as much either," he said. "It is rare to have these consequences as long as counseling takes place."

Dr. Östlund reminded listeners that bariatric surgery has many health benefits, and the risk for alcoholism should be viewed in the context of these.

She noted that the study's strengths were that it was a nationwide sample, with findings based on comprehensive registry data. "But we had no data on weight development, and different selection criteria may have been applied for the different procedures," she reported.

"Still, we can conclude that the total bariatric surgery cohort had an increased risk for inpatient treatment for the psychiatric disorders we studied," she said.

Vivek N. Prachand, MD, codirector of the Center for the Surgical Treatment of Obesity at the University of Chicago Pritzker School of Medicine, in Illinois, noted that the study might be "comparing apples and oranges" in evaluating the bariatric population with regard to a normal-weight healthy population. Instead, a better comparison would be the bariatric population with a very obese population not undergoing weight-loss surgery, he suggested. "It could be that the differences you found might be seen in a morbidly obese population in general. The differences may not be reflecting the surgery treatment," he suggested.

Dr. Östlund, Dr. Morton, and Dr. Prachand have disclosed no relevant financial relationships.

Digestive Disease Week (DDW) 2011: Abstract 266. Presented May 7, 2011.

Authors and Disclosures

Journalist

Caroline Helwick

 

Docj
on 10/12/11 5:34 am
Revision on 09/01/88
Seems they missed the bigger picture. 

Research I conducted at U.S.C. in 94', revealed a danger of "symptom substitution" re. a tendency to switch addictive behaviors. In other words, most likely because they couldn't eat like before, WlS folks sometimes started abusing things such as ETOH, drugs, shopping (a big one for some reason ? a need for new clothes...), gambling, sex, etc.

This is nothing new.
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